From I-77 North - Exit 73B. Take Highway 421 North to exit 286B. Make a left at the light. At the second light turn left and the hotel is on the immediate right. From I-40 West - Take I-40 West to 421 North to Exit 286B. Make a left at the light. At the second light turn left and hotel is on the immediate right. From 421 North - Exit 286B and make a left at the light. At the second light turn left and hotel is on the immediate right. From 421 South - Exit 286B then make a right at the THIS HOTEL IS 100PCT NON SMOKING The Hampton Inn Wilkesboro hotel is located on the corner of Highway 268 and Collegiate Drive just minutes from the majestic Blue Ridge Mountains of North Carolina. This Wilkesboro Hampton Inn is within walking distance of the Wilkes Community College campus and a short drive to both historic Wilkesboro and North Wilkesboro downtown areas. Within .5 miles of the North Carolina Hampton Inn Wilkesboro you can dine at Sagebrush Steakhouse Burger King Kabuki Japanese Steak House Wendy*s or Don*s Seafood. The Hampton Inn Wilkesboro North Carolina is a hotel where the rooms are filled with amenities sure to please the busy executive or leisure traveler. Each hotel room features refrigerator microwave coffeemaker iron ironing board and hair dryer as well as high-speed internet access and cable TV with movie channel. Guests at this Wilkesboro North Carolina hotel can request a king suite with whirlpool tub connecting rooms or cribs as an added convenience. Hotel guests at this North Carolina Hampton Inn in Wilkesboro will enjoy complimentary On the House hot breakfast buffet served daily and Monday through Friday complimentary On the Run Breakfast Bags and USA Today newspaper. The Hampton Inn Wilkesboro hotel provides the convenience of complimentary wireless high-speed internet in the lobby meeting rooms and all public areas as well as coffee and tea 24 hours a day in the hotel lobby. Hampton Inn Wilkesboro North Carolina hotel guests have the added luxury of relaxing in the swimming pool or dry sauna working out in our fitness center or utilizing the hotel business center laundry and valet services or meeting and banquet rooms. All stays at the Hampton Inn Wilkesboro hotel in North Carolina are backed by our 100 satisfaction guarantee. If you*re not satisfied we don*t expect you to pay. That*s 100 Hampton. We love having you here at the Hampton Inn Wilkesboro North Carolina. Parking light. At the next light make a left.