Greensboro/Raleigh Continue Onto I-40 to Winston-Salem Merge onto Exit 188/US-421N Toward Wilkesboro Until You Reach US-221N to West Jefferson. Charlotte NC Follow I-77N/Statesville. Take Exit 73B and Merge Onto US-421N Toward Wilkesboro Until You Reach US-221N to West Jefferson. Boone NC Follow US-421S Until You Reach US-221N to West Jefferson. Make Left at First Traffic Hotel on Right .2 Miles. The Hampton Inn West Jefferson North Carolina hotel is located in beautiful High Country with breathtaking views and old fashioned hospitality. Rooms at the Hampton Inn West Jefferson North Carolina hotel offer all the amenities to make your stay a memorable experience. Our Hampton Inn hotel has a Fitness Center and indoor pool open year round. Come stay at our Hampton Inn West Jefferson North Carolina hotel and enjoy a day of outdoor adventure such as golf fly fishing canoeing hiking or just relaxing taking in the scenery. We love having you here at the Hampton Inn West Jefferson North Carolina hotel. Parking