From I-75 Northbound - Take Exit 81 - turn right onto US Highway 321 - go straight for less than a half mile - make a left on Ft. Loudon Medical Center Drive /next to Chili*s/. From I-75 Southbound - Take Exit 81 - turn left onto US Highway 321 - go straight for less than a half mile - make a left on Ft. Loudon Medical Center Drive / Next to Chili*s/. From I-40 Eastbound- Take Exit 364 /Oak Ridge/Melton Hill/ turn right onto Hwy 95 which turns into Hwy 321 go approximately 5 miles -make a The Hampton Inn Lenoir City hotel is an interior corridor property conveniently located at Exit 81 off Tennessee Interstate 75. A variety of restaurants are located near our hotel. The Hampton Inn Lenoir City offers a daily complimentary On the House hot breakfast as well as coffee and tea in the lobby. Our hotel also features a 24-hour Suite Shop. In each room guests can enjoy both wired and wireless high-speed internet access pay-per-view movies and complimentary local calls. The William Lenoir meeting room of our hotel can accommodate any event from business meetings to wedding receptions. Our outdoor pool and on-site exercise room will keep you on track during your stay. We love having you here in Tennessee at the Hampton Inn Lenoir City. Parking left onto Loudon County Medical Center Drive / next to Chili*s/. Top of the drive we are on the left.