I-45 South Take exit 20 for Baicliff/Sante Fe. Stay in the right lane to the overpass of Hwy 646. Turn left at the next light toward I-45N. Drive 1/2 mile on service road. The hotel is on the right. Stay Your Way at the Hampton Inn and Suites Houston/League City TX. Just 25 miles south of Downtown Houston and 20 miles North of Galveston Island we are located off of Interstate 45. our hotel*s location is convenient for all traveler. Whether you*re here for business or pleasure the Hampton Inn - Suites Houston/League City has much to offer. Regardless of your reason for staying with us you*ll be able to enjoy our fantastic amenities like the refreshing outdoor pool and whirlpool the well-equipped fitness center and our daily free hot breakfast buffet. Make your reservations today to take advantage of everything we have to offer. Parking