From I-40 Exit 398 /Strawberry Plains Pike/ and follow the signs. The hotel is 0.2 mile from the interstate. The nearest cross streets are Strawberry Plains Pike and Huckleberry Springs Road. From the Airport Take the Alcoa Hwy north to I-40 East to Exit 398 and turn left. This Property is 100 Pct. Non-smoking The Hampton Inn Knoxville-East hotel offers you a convenient location off Interstate 40 /Exit 398/ in east Knoxville Tennessee. The Hampton Inn hotel is within a short drive of downtown Knoxville the University of Tennessee Great Smoky Mountain National Park Dollywood theme park and much more. Our beautifully appointed Hampton Inn hotel features interior corridors and our rooms offer complimentary wireless high-speed Internet access 32** high-definition TV*s and much more. The hotel also has an indoor pool suite shop complimentary hot breakfast and more. We love having you here at the Hampton Inn Knoxville-East hotel. Parking