Out hotel in Jacksonville Florida is central located near Jacksonville attractions and highways From Jacksonville Airport - Take I-95 South to I-295 South - 19 miles to 10 and take I-10 West to Exit 351 - bear right and hotel is on the left behind Wendy and McDonald Shopping Plaza. From I-95 - Take I-10 West to Exit 351 - bear right and hotel is on the left behind Wendy and McDonald Shopping Plaza. From I-10 going east - Take Exit 351 - bear left and hotel is on the left behind McDonald. From Whether traveling to Jacksonville on business or pleasure this new contemporary Hampton Inn Jacksonville I-10 West FL hotel is gorgeous and has exactly what you want. Located just off Exit 351 of Florida interstate I-10 it is in close proximity to downtown Jacksonville Florida and also to commercial and industrial areas. This Florida Hampton Inn hotel provides comfortable rooms standard with a coffeemaker iron and board high-speed internet access and complimentary movie channel. Jacksonville Hampton Inn hotel guests also enjoy On the House hot breakfast On the Run breakfast bags /Monday-Friday/ wireless internet access in the lobby meeting rooms and public areas coffee and tea in the hotel lobby 24 hours a day and USA Today copies Monday through Friday. We love having you here at the Hampton Inn Jacksonville Florida hotel. Parking Daytona Beach - Take I-95 North to I-10 West at Exit 351 and bear right.