When using GPS use VAN NUYS for the city From LAX Airport - Take 405 North Exit on Burbank Blvd. and turn right. Make a left onto Sepulveda Blvd. proceed 1/2 block. The hotel will be on the right hand side. From Downtown Los Angeles - Take 101 North Exit Sepulveda Blvd. and turn right. Proceed about 1 mile and the hotel will be on the right after Burbank Blvd. The Hampton Inn - Suites Los Angeles Van Nuys Hotel California features 96 luxurious guest rooms and suites with all the amenities today*s business and leisure travelers expect. The Hampton Inn - Suites Los Angeles Van Nuys Hotel California is located north of Los Angeles just off of freeways 405 and 101. 6 miles north of the Universal Studios Park. We love having you here at the Hampton Inn - Suites Los Angeles Van Nuys Hotel California. Parking