Delight in nearby downtown Palo Alto, explore San Francisco and Napa Valley, or simply relax at our scenic hotel, set amongst lush gardens. There's plenty to see and do while in Palo Alto, the heart of the San Francisco Bay area. Take a tour of the Stanford Campus, stroll through local museums and gardens, visit the shops on University Avenue in downtown Palo Alto, or take a quick walk across the street to the nationally recognized Stanford Shopping Center.Just one block away, the Cal Train offers a 50-minute train ride into downtown San Francisco where you can take in all the sites - Fisherman's Wharf, Union Square, or Chinatown. Go wine tasting in the beautiful Napa Valley, just one scenic hour drive away, or head south two hours to see the Pacific Coast, Monterey, and Carmel areas. Take Interstate 280 South and exit onto Page Mill Road East. Proceed approximately two miles and turn left onto El Camino Real. The hotel is located two miles down and on the right side. Set amidst picturesque water and flower gardens and koi ponds, the Sheraton Palo Alto Hotel is a source of familiar comfort in the Silicon Valley. Our resort-like setting welcomes you. After spending a full day browsing downtown Palo Altos charming boutiques, art galleries, and restaurants, return for a quick swim or workout.  Retreat to one of our 346 spacious guest rooms, many of which feature a patio or balcony. Share our elegantly-appointed facilities with 10 to 500 people for a unique wedding reception, banquet, or business conference. A 24-hour business center, wireless Internet access, and a lobby concierge will keep you connected, even when miles away from home. The entrance to Stanford University is just outside our door. You can also take the nearby Cal Train and explore Fishermans Wharf, Union Square, or Chinatown. Or enjoy a scenic drive to Napa Valley for some wine tasting and beautiful views. Enjoy the beauty of the San Francisco Bay area while connecting with loved ones at the Sheraton Palo Alto Hotel. Parking Take Highway 101 South to Embarcadero Road West. Proceed approximately two miles and turn right onto El Camino Real. The hotel is located three blocks down and on the right side.