From Highway 59 North - Hotel is on the right - one block south of Loop 224. From Highway 59 South - Loop 224 South to 59 South Exit. Hotel is on the left - one block south of Loop 224. From Highway 259 - Highway 21 and Highway 7 are the same as 59 South . Cross Streets - Highway 59 South and Loop 224. The newest hotel in the oldest town in Texas the Hampton Inn - Suites Nacogdoches hotel is conveniently located on Highway 59 South with easy access to area companies and Stephen F. Austin State University and Historic Downtown Nacogdoches. Our Nacogdoches Hampton Inn - Suites hotel will meet your business or leisure travel needs. We are a three story hotel with spacious amenity filled rooms and suites that feature complimentary high-speed internet access and a complimentary deluxe hot breakfast buffet served daily. We love having you here in Texas at the Hampton Inn - Suites Nacogdoches hotel. Parking